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Что (кто) такое mitosis$49692$ - определение
![An abnormal (tripolar) mitosis (12 o'clock position) in a precancerous lesion of the stomach ([[H&E stain]])](https://commons.wikimedia.org/wiki/Special:FilePath/Atypical mitosis.jpg?width=200 "An abnormal (tripolar) mitosis (12 o'clock position) in a precancerous lesion of the stomach ([[H&E stain]])")
![actomyosin cortex]] is depicted in red, DNA/chromosomes purple, [[microtubules]] green, and membrane and retraction fibers in black. Rounding also occurs in live tissue, as described in the text.](https://commons.wikimedia.org/wiki/Special:FilePath/Cell-shape-mitosis.png?width=200 "actomyosin cortex]] is depicted in red, DNA/chromosomes purple, [[microtubules]] green, and membrane and retraction fibers in black. Rounding also occurs in live tissue, as described in the text.")
![Mitosis divides the [[chromosome]]s in a [[cell nucleus]].](https://commons.wikimedia.org/wiki/Special:FilePath/Major events in mitosis.svg?width=200 "Mitosis divides the [[chromosome]]s in a [[cell nucleus]].")
![A cell in late [[metaphase]]. All chromosomes (blue) but one have arrived at the metaphase plate.](https://commons.wikimedia.org/wiki/Special:FilePath/Mitosis-fluorescent.jpg?width=200 "A cell in late [[metaphase]]. All chromosomes (blue) but one have arrived at the metaphase plate.")
![Label-free [[live cell imaging]] of Mesenchymal Stem Cells undergoing mitosis](https://commons.wikimedia.org/wiki/Special:FilePath/Mitosis Mesenchymal Stem Cells.gif?width=200 "Label-free [[live cell imaging]] of Mesenchymal Stem Cells undergoing mitosis")
![Cilliate undergoing cytokinesis, with the [[cleavage furrow]] being clearly visible](https://commons.wikimedia.org/wiki/Special:FilePath/Unk.cilliate.jpg?width=200 "Cilliate undergoing cytokinesis, with the [[cleavage furrow]] being clearly visible")
![Onion ([[Allium]]) cells in different phases of the cell cycle enlarged 800 diameters.<br /> a. non-dividing cells<br />b. nuclei preparing for division (spireme-stage) <br />c. dividing cells showing mitotic figures <br />e. pair of daughter-cells shortly after division](https://commons.wikimedia.org/wiki/Special:FilePath/Wilson1900Fig2.jpg?width=200 "Onion ([[Allium]]) cells in different phases of the cell cycle enlarged 800 diameters.<br /> a. non-dividing cells<br />b. nuclei preparing for division (spireme-stage) <br />c. dividing cells showing mitotic figures <br />e. pair of daughter-cells shortly after division")
![Normal and atypical forms of mitosis in cancer cells. A, normal mitosis; B, [[chromatin bridge]]; C, multipolar mitosis; D, ring mitosis; E, dispersed mitosis; F, asymmetrical mitosis; G, lag-type mitosis; and H, micronuclei. H&E stain.](https://commons.wikimedia.org/wiki/Special:FilePath/Normal versus atypical mitosis.jpg?width=200 "Normal and atypical forms of mitosis in cancer cells. A, normal mitosis; B, [[chromatin bridge]]; C, multipolar mitosis; D, ring mitosis; E, dispersed mitosis; F, asymmetrical mitosis; G, lag-type mitosis; and H, micronuclei. H&E stain.")
Википедия
Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered first in frog eggs. It stimulates the mitotic and meiotic phases of the cell cycle. MPF promotes the entrance into mitosis (the M phase) from the G2 phase by phosphorylating multiple proteins needed during mitosis. MPF is activated at the end of G2 by a phosphatase, which removes an inhibitory phosphate group added earlier.
The MPF is also called the M phase kinase because of its ability to phosphorylate target proteins at a specific point in the cell cycle and thus control their ability to function.
